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    Klra3 killer cell lectin-like receptor, subfamily A, member 3 [ Mus musculus (house mouse) ]

    Gene ID: 16634, updated on 25-Apr-2024

    Summary

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    Official Symbol
    Klra3provided by MGI
    Official Full Name
    killer cell lectin-like receptor, subfamily A, member 3provided by MGI
    Primary source
    MGI:MGI:101905
    See related
    Ensembl:ENSMUSG00000067591 AllianceGenome:MGI:101905
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5E6; Nk2; Nk-2; Ly49c; Nk2.1; NK-2.1
    Summary
    Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    Location:
    6 F3; 6 63.44 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (130300252..130314589, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (130323289..130337626, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene killer cell lectin-like receptor subfamily A, member 13, pseudogene Neighboring gene predicted gene, 24072 Neighboring gene killer cell lectin-like receptor, subfamily A, member 1 Neighboring gene predicted gene 6584

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Dynamic allostery controls the peptide sensitivity of the Ly49C natural killer receptor. Ma J, et al. J Biol Chem, 2021 Jan-Jun. PMID 33891944, Free PMC Article
    2. Ly49C-dependent control of MCMV Infection by NK cells is cis-regulated by MHC Class I molecules. Forbes CA, et al. PLoS Pathog, 2014 May. PMID 24873973, Free PMC Article
    3. Suppression of graft-versus-host disease after adoptive infusion of alloreactive NK cells induced by silencing Ly49C gene in mice. Cao D, et al. Transpl Immunol, 2009 Mar. PMID 19010415
    4. NK cell inhibitory receptor Ly-49C residues involved in MHC class I binding. Sundbäck J, et al. J Immunol, 2002 Jan 15. PMID 11777974
    5. The NK2.1 receptor is encoded by Ly-49C and its expression is regulated by MHC class I alleles. Gosselin P, et al. Int Immunol, 1997 Apr. PMID 9138013

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dynamic allostery controls the peptide sensitivity of the Ly49C natural killer receptor.
      Title: Dynamic allostery controls the peptide sensitivity of the Ly49C natural killer receptor.
    2. The Ly49 family of class I MHC receptors have critical role for adaptive natural killer cell responses.
      Title: Critical role for the Ly49 family of class I MHC receptors in adaptive natural killer cell responses.
    3. Clearance of lung cancer is facilitated by up-regulation of NKG2D, NKp46, and other activating receptors upon exposure to environmental MHCI. Surface expression of the inhibitory receptor Ly49C/I, on the other hand, is down-regulated upon exposure to tumor-bearing tissue.
      Title: Modulation of NKG2D, NKp46, and Ly49C/I facilitates natural killer cell-mediated control of lung cancer.
    4. This docking mode was conserved with that previously observed for Ly49C.H-2K(b) Indeed, structure-guided mutation of Ly49C indicated that Ly49C.H2-Q10 and Ly49C.H-2K(b) possess similar energetic footprints focused around residues located within the Ly49C beta4-stand and L5 loop, which contact the underside of the peptide-binding platform floor.
      Title: Recognition of the Major Histocompatibility Complex (MHC) Class Ib Molecule H2-Q10 by the Natural Killer Cell Receptor Ly49C.
    5. murine cytomegalovirus infection results in altered NK cell activation
      Title: Ly49C-dependent control of MCMV Infection by NK cells is cis-regulated by MHC Class I molecules.
    6. we have shown for the first time how the differential expression of the Ly49 inhibitory receptors during ontogeny can affect NK cell function
      Title: Cutting edge: Ly49C/I⁻ neonatal NK cells predispose newborns to autoimmune ovarian disease induced by maternal autoantibody.
    7. This study showed that mPer2 is a critical clock component in modulating circadian rhythms in bone marrow, and it implies that Ly49C and Nkg2d may play an important role in mediating mPer2-controlled cytotoxic response.
      Title: Expression profiling reveals a positive regulation by mPer2 on circadian rhythm of cytotoxicity receptors: Ly49C and Nkg2d.
    8. adoptive infusion of alloreactive NK cells with silenced Ly49C gene results in suppression of graft-versus-host disease
      Title: Suppression of graft-versus-host disease after adoptive infusion of alloreactive NK cells induced by silencing Ly49C gene in mice.
    9. signaling through the mouse NK inhibitory receptor Ly49C requires the presence of H-2Kb and this signaling is prevented when H-2Kb is ablated by pulsing with a peptide that can bind to it with high affinity
      Title: Influence of xenogeneic beta2-microglobulin on functional recognition of H-2Kb by the NK cell inhibitory receptor Ly49C.
    10. The repertoire of inhibitory Ly49 receptors may be formed under the influenced of Fyn-dependent NK cell activation as well as the respective MHC class I environment.
      Title: A role for the src family kinase Fyn in NK cell activation and the formation of the repertoire of Ly49 receptors.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC123910

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    killer cell lectin-like receptor 3
    Names
    T-cell surface glycoprotein Ly-49C
    lymphocyte antigen 49c
    natural killer cell-associated antigen 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289604.1 → NP_001276533.1  killer cell lectin-like receptor 3

      See identical proteins and their annotated locations for NP_001276533.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon structure in the 3' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AC087336
      Consensus CDS
      CCDS20601.1
      UniProtKB/Swiss-Prot
      Q3TWQ1, Q3ZB40, Q499I4, Q61154, Q61198, Q64257, Q64329
      UniProtKB/TrEMBL
      Q9JHN9
      Related
      ENSMUSP00000085333.5, ENSMUST00000088017.5
      Conserved Domains (2) summary
      cd03593
      Location:145 → 259
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
      pfam08391
      Location:40 → 157
      Ly49; Ly49-like protein, N-terminal region

    2. NM_001289605.1 → NP_001276534.1  killer cell lectin-like receptor 3

      See identical proteins and their annotated locations for NP_001276534.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 5' UTR and contains an alternate exon structure in the 3' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AC087336
      Consensus CDS
      CCDS20601.1
      UniProtKB/Swiss-Prot
      Q3TWQ1, Q3ZB40, Q499I4, Q61154, Q61198, Q64257, Q64329
      UniProtKB/TrEMBL
      Q9JHN9
      Conserved Domains (2) summary
      cd03593
      Location:145 → 259
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
      pfam08391
      Location:40 → 157
      Ly49; Ly49-like protein, N-terminal region

    3. NM_010648.3 → NP_034778.2  killer cell lectin-like receptor 3

      See identical proteins and their annotated locations for NP_034778.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AC087336, AK159595, BX515458, U56404
      Consensus CDS
      CCDS20601.1
      UniProtKB/Swiss-Prot
      Q3TWQ1, Q3ZB40, Q499I4, Q61154, Q61198, Q64257, Q64329
      UniProtKB/TrEMBL
      Q9JHN9
      Related
      ENSMUSP00000107629.3, ENSMUST00000111998.9
      Conserved Domains (2) summary
      cd03593
      Location:145 → 259
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
      pfam08391
      Location:40 → 157
      Ly49; Ly49-like protein, N-terminal region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      130300252..130314589 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q64329.2 GenPept UniProtKB/Swiss-Prot:Q64329

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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